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USING DNA ORIGAMI FOR

A NANOSCALE ELECTROCHEMICAL POSITIONER MODEL

Presented by Team Toehold Conga Nanny

[1] N. Arroyo-Currás, J. Somerson, P. A. Vieira, K. L. Ploense, T. E. Kippin, K. W. Plaxco, 'Real-time measurement of small molecules directly in awake, ambulatory animals', Proceedings of the National Academy of Sciences 2017, 114, 645.

 

[2] A. A. Lubin, K. W. Plaxco, 'Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures', Accounts of chemical research 2010, 43, 496.

 

[3] D. Kang, C. Parolo, S. Sun, N. E. Ogden, F. W. Dahlquist, K. W. Plaxco, 'Expanding the Scope of Protein-Detecting Electrochemical DNA “Scaffold” Sensors', ACS Sensors 2018, 3, 1271. 

 

[4] D. Kang, S. Sun, M. Kurnik, D. Morales, F. W. Dahlquist, K. W. Plaxco, 'New Architecture for Reagentless, Protein-Based Electrochemical Biosensors', Journal of the American Chemical Society 2017, 139, 12113.

 

[5] F. Hong, F. Zhang, Y. Liu, H. Yan, 'DNA origami: scaffolds for creating higher order structures', Chemical reviews 2017, 117, 12584. 

 

[6] Y. R. Yang, Y. Liu, H. Yan, 'DNA Nanostructures as Programmable Biomolecular Scaffolds', Bioconjugate Chemistry 2015, 26, 1381.

 

[7] J. J. Funke, H. Dietz, 'Placing molecules with Bohr radius resolution using DNA origami', Nature nanotechnology 2016, 11, 47.

 

[8] H. Li, N. Arroyo-Currás, D. Kang, F. Ricci, K. W. Plaxco, 'Dual-Reporter Drift Correction To Enhance the Performance of Electrochemical Aptamer-Based Sensors in Whole Blood', Journal of the American Chemical Society 2016, 138, 15809.


[9] Y. Du, B. J. Lim, B. Li, Y. S. Jiang, J. L. Sessler, A. D. Ellington, 'Reagentless, Ratiometric Electrochemical DNA Sensors with Improved Robustness and Reproducibility', Analytical Chemistry 2014, 86, 8010.

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ACKNOWLEDGEMENTS

  • Tong Wang at ASRC Center at CUNY for TEM Imaging

  • Jonas Funke at TUM Munich for helping to convert positioner design to a commercially available plasmid

  • Earlier research members Muaz, Alex, Carlotta

  • ARO (Army Research Office)

  • St. John’s College, St. John's University, New York

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